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Product Details
PA5-20269
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from near the amino terminus of human Bfl-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11156205
Product Specific Information
Despite the predicted molecular weight, Bfl-1 often migrates at a higher molecular weight in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is mouse kidney tissue lysate.
PA5-20269 can be used with blocking peptide PEP-0384.
Target Information
Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A1-A; B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1a; B-cell leukemia/lymphoma 2 related protein A1d; Bcl-2-like protein 5; Bcl-2-related protein A1; Bcl2-L-5; BCL2-related protein A1; BCL2-related protein A1d; GRS protein; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
Gene Aliases: A1; ACC-1; ACC-2; ACC1; ACC2; BB218357; BCL2A1; Bcl2a1a; Bcl2a1d; BCL2L5; Bfl-1; BFL1; GRS; HBPA1
UniProt ID: (Human) Q16548, (Mouse) Q07440
Entrez Gene ID: (Human) 597, (Rat) 170929, (Mouse) 12044
release of cytochrome c from mitochondria
mitochondrial fusion
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
apoptotic process
T cell differentiation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
T cell receptor signaling pathway
B cell homeostasis
negative regulation of B cell apoptotic process
regulation of apoptotic process
negative regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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