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Product Details
H00010017-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCL2L10 (NP_065129, 1 a.a. approximately 204 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVDQLRERTT MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER GPLVTARWKK WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC LLTTAFIYLW TRLL
Target Information
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anti-apoptotic protein Boo; Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B; Bcl-2-like protein 10; Bcl2-L-10; BCL2-like 10 (apoptosis facilitator); death inducer binding to vBcl-2 and Apaf-1
Gene Aliases: BCL-B; bcl2-L-10; BCL2L10; BCLB; BOO; DIVA
UniProt ID: (Human) Q9HD36
Entrez Gene ID: (Human) 10017
activation of cysteine-type endopeptidase activity involved in apoptotic process
spermatogenesis
female gamete generation
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of apoptotic process
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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