Proteintech

BCL2L13 Polyclonal Antibody

BCL2L13 Antibody in Immunocytochemistry (ICC/IF)

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BCL2L13 Antibody (16612-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using BCL2L13 antibody 16612-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

BCL2L13 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BCL2L13 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16612-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BCL2L13 Fusion Protein Ag9841 (1-300 aa encoded by BC003032)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLLELTRRG QEPLSALLQF GVTYLEDYSA EYIIQQGGWG TVFSLESEEE EYPGITAEDS NDIYILPSDN SGQVSPPESP TVTTSWQSES LPVSLSASQS WHTESLPVSL GPESWQQIAM DPEEVKSLDS NGAGEKSENN SSNSDIVHVE KEEVPEGMEE AAVASVVLPA RELQEALPEA PAPLLPHITA TSLLGTREPD TEVITVEKSS PATSLFVELD EEEVKAATTE PTEVEEVVPA LEPTETLLSE KEINAREESL VEELSPASEK KPVPPSEGKS RLSPAGEMKP MPLSEGKSIL L (1-300 aa encoded by BC003032)

Target Information

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.

Metabolic brain disease

Fang Q,Zheng S,Chen Q,Chen L,Yang Y,Wang Y,Zhang H,Chen J

Wed Feb 01 00:00:00 UTC 2023

Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Neuron

Kallergi E,Siva Sankar D,Matera A,Kolaxi A,Paolicelli RC,Dengjel J,Nikoletopoulou V

Wed Aug 02 00:00:00 UTC 2023

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

PLoS genetics

Kremer LS,Bozhilova LV,Rubalcava-Gracia D,Filograna R,Upadhyay M,Koolmeister C,Chinnery PF,Larsson NG

Sun Jan 01 00:00:00 UTC 2023

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc.

Autophagy

Madhu V,Hernandez-Meadows M,Boneski PK,Qiu Y,Guntur AR,Kurland IJ,Barve RA,Risbud MV

Thu Jun 01 00:00:00 UTC 2023

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.

Cell death & disease

Liu K,Zhao Q,Sun H,Liu L,Wang C,Li Z,Xu Y,Wang L,Zhang L,Zhang H,Chen Q,Zhao T

Mon Apr 11 00:00:00 UTC 2022

Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.

Cancer cell international

Meng F,Zhang L,Zhang M,Ye K,Guo W,Liu Y,Yang W,Zhai Z,Wang H,Xiao J,Dai H

Wed Jun 30 00:00:00 UTC 2021

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains.

Autophagy

Wu X,Zheng Y,Liu M,Li Y,Ma S,Tang W,Yan W,Cao M,Zheng W,Jiang L,Wu J,Han F,Qin Z,Fang L,Hu W,Chen Z,Zhang X

Sun Aug 01 00:00:00 UTC 2021

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.

Autophagy

da Silva Rosa SC,Martens MD,Field JT,Nguyen L,Kereliuk SM,Hai Y,Chapman D,Diehl-Jones W,Aliani M,West AR,Thliveris J,Ghavami S,Rampitsch C,Dolinsky VW,Gordon JW

Wed Sep 01 00:00:00 UTC 2021

Neuroglial transmitophagy and Parkinson's disease.

Glia

Morales I,Sanchez A,Puertas-Avendaño R,Rodriguez-Sabate C,Perez-Barreto A,Rodriguez M

Sun Nov 01 00:00:00 UTC 2020

Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.

International immunopharmacology

Zhang X,Huang CR,Pan S,Pang Y,Chen YS,Zha GC,Guo KJ,Zheng X

Mon Jun 01 00:00:00 UTC 2020

The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.

The Journal of biological chemistry

Fujiwara M,Tian L,Le PT,DeMambro VE,Becker KA,Rosen CJ,Guntur AR

Fri Aug 23 00:00:00 UTC 2019

Degradation of altered mitochondria by autophagy is impaired in Lafora disease.

The FEBS journal

Lahuerta M,Aguado C,Sánchez-Martín P,Sanz P,Knecht E

Fri Jun 01 00:00:00 UTC 2018

Degradation of altered mitochondria by autophagy is impaired in Lafora disease.

The FEBS journal

Lahuerta M,Aguado C,Sánchez-Martín P,Sanz P,Knecht E

Fri Jun 01 00:00:00 UTC 2018

A novel role for Bcl2l13 in promoting beige adipocyte biogenesis.

Biochemical and biophysical research communications

Ju L,Chen S,Alimujiang M,Bai N,Yan H,Fang Q,Han J,Ma X,Yang Y,Jia W

Fri Nov 30 00:00:00 UTC 2018

A novel role for Bcl2l13 in promoting beige adipocyte biogenesis.

Biochemical and biophysical research communications

Ju L,Chen S,Alimujiang M,Bai N,Yan H,Fang Q,Han J,Ma X,Yang Y,Jia W

Fri Nov 30 00:00:00 UTC 2018

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.

Human molecular genetics

Siegmund SE,Yang H,Sharma R,Javors M,Skinner O,Mootha V,Hirano M,Schon EA

Fri Dec 01 00:00:00 UTC 2017

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.

Human molecular genetics

Siegmund SE,Yang H,Sharma R,Javors M,Skinner O,Mootha V,Hirano M,Schon EA

Fri Dec 01 00:00:00 UTC 2017

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.

Nature communications

Murakawa T,Yamaguchi O,Hashimoto A,Hikoso S,Takeda T,Oka T,Yasui H,Ueda H,Akazawa Y,Nakayama H,Taneike M,Misaka T,Omiya S,Shah AM,Yamamoto A,Nishida K,Ohsumi Y,Okamoto K,Sakata Y,Otsu K

Mon Jul 06 00:00:00 UTC 2015

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.

Nature communications

Murakawa T,Yamaguchi O,Hashimoto A,Hikoso S,Takeda T,Oka T,Yasui H,Ueda H,Akazawa Y,Nakayama H,Taneike M,Misaka T,Omiya S,Shah AM,Yamamoto A,Nishida K,Ohsumi Y,Okamoto K,Sakata Y,Otsu K

Mon Jul 06 00:00:00 UTC 2015

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.

Proceedings of the National Academy of Sciences of the United States of America