Proteintech

BCL2L2 Polyclonal Antibody

BCL2L2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

BCL2L2 Antibody (16026-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 16026-1-AP ( BCL2L2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

16026-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BCL2L2 Fusion Protein Ag8863 (1-171 aa encoded by BC021198)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATPASAPD TRALVADFVG YKLRQKGYVC GAGPGEGPAA DPLHQAMRAA GDEFETRFRR TFSDLAAQLH VTPGSAQQRF TQVSDELFQG GPNWGRLVAF FVFGAALCAE SVNKEMEPLV GQVQEWMVAY LETRLADWIH SSGGWAEFTA LYGDGALEEA RRLREGNWAS VR (1-171 aa encoded by BC021198)

Target Information

Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization.

Neural regeneration research

Yu Y,Xia LK,Di Y,Nie QZ,Chen XL

Mon May 01 00:00:00 UTC 2023

Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins.

Cancers

Yamamoto M,Suzuki S,Togashi K,Sugai A,Okada M,Kitanaka C

Sun Mar 27 00:00:00 UTC 2022

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.

Nature communications

Kohli J,Ge C,Fitsiou E,Doepner M,Brandenburg SM,Faller WJ,Ridky TW,Demaria M

Fri Dec 23 00:00:00 UTC 2022

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.

Nature communications

Kohli J,Ge C,Fitsiou E,Doepner M,Brandenburg SM,Faller WJ,Ridky TW,Demaria M

Fri Dec 23 00:00:00 UTC 2022

GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts.

European journal of pharmacology

Wang SH,Cui LG,Su XL,Komal S,Ni RC,Zang MX,Zhang LR,Han SN

Tue Apr 05 00:00:00 UTC 2022

HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6.

iScience

Yin M,Cheng M,Liu C,Wu K,Xiong W,Fang J,Li Y,Zhang B

Fri Nov 19 00:00:00 UTC 2021

Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.

Oxidative medicine and cellular longevity

Yang F,He X,Chen T,Liu J,Luo Z,Sun S,Qin D,Huang W,Tang Y,Liu C,Luo F

Fri Mar 04 00:00:00 UTC 2022

MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Yang T,Thakur A,Chen T,Yang L,Lei G,Liang Y,Zhang S,Ren H,Chen M

Mon Jun 01 00:00:00 UTC 2015

MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Yang T,Thakur A,Chen T,Yang L,Lei G,Liang Y,Zhang S,Ren H,Chen M

Mon Jun 01 00:00:00 UTC 2015

Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.

PloS one

Yu G,Jiang L,Xu Y,Guo H,Liu H,Zhang Y,Yang H,Yuan C,Ma J

Tue May 07 00:00:00 UTC 2013

Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.

PloS one

Yu G,Jiang L,Xu Y,Guo H,Liu H,Zhang Y,Yang H,Yuan C,Ma J

Tue May 07 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; c98; protein phosphatase 1, regulatory subunit 51

View more View less

Gene Aliases: AW048834; BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCL2L2; BCLW; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51

View more View less

UniProt ID: (Human) Q92843, (Mouse) P70345

View more View less

Entrez Gene ID: (Human) 599, (Mouse) 12050, (Rat) 60434

View more View less

Function(s)

protein binding protein homodimerization activity protein heterodimerization activity BH domain binding

Process(es)

spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of apoptotic process Sertoli cell proliferation extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway apoptotic process regulation of apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

BCL2L2 Polyclonal Antibody

BCL2L2 Antibody (16026-1-AP) in IHC (P)

Product Details

16026-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!