Proteintech

BCL6 Polyclonal Antibody

BCL6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BCL6 Antibody (21187-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using 21187-1-AP ( BCL6 Antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Sodium Citrate buffer (pH6).

BCL6 Antibody in Immunoprecipitation (IP)

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Product Details

21187-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BCL6 Fusion Protein Ag15519 (183-532 aa encoded by BC150184)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SLYSGLSTP PASYSMYSHL PVSSLLFSDE EFRDVRMPVA NPFPKERALP CDSARPVPGE YSRPTLEVSP NVCHSNIYSP KETIPEEARS DMHYSVAEGL KPAAPSARNA PYFPCDKASK EEERPSSEDE IALHFEPPNA PLNRKGLVSP QSPQKSDCQP NSPTESCSSK NACILQASGS PPAKSPTDPK ACNWKKYKFI VLNSLNQNAK PEGPEQAELG RLSPRAYTAP PACQPPMEPE NLDLQSPTKL SASGEDSTIP QASRLNNIVN RSMTGSPRSS SESHSPLYMH PPKCTSCGSQ SPQHAEMCLH TAGPTFPEEM GETQSEYSDS SCENGAFFCN ECDCRFSEEA S (183-532 aa encoded by BC150184)

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Acta biochimica et biophysica Sinica

Du P,Meng L,Liao X,Liu Y,Mo X,Gong M,Liao Y

Wed Jan 25 00:00:00 UTC 2023

B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36.

Cell death & disease

Zhang H,Li Y,Zhang C,Huang K,Zhao J,Le S,Jiang L,Liu H,Yang P,Xiao X,Yu J,Wu J,Ye P,Xia J

Mon Apr 18 00:00:00 UTC 2022

MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.

Placenta

Chen X,Song QL,Ji R,Wang JY,Li ZH,Guo D,Yin TL,Wang SJ,Yang J

Tue Feb 01 00:00:00 UTC 2022

Transcriptional inhibition of miR-486-3p by BCL6 upregulates Snail and induces epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis.

Respiratory research

Yan Z,Ao X,Liang X,Chen Z,Liu Y,Wang P,Wang D,Liu Z,Liu X,Zhu J,Zhou S,Zhou P,Gu Y

Thu Apr 28 00:00:00 UTC 2022

Conditional Knockout Mouse Models to Study the Roles of Individual NF-κB Transcription Factors in Lymphocytes.

Methods in molecular biology (Clifton, N.J.)

Adams EJ,De Silva NS,Klein U

Mon Jan 10 00:00:00 UTC 2022

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6.

Molecular medicine reports

Zhang S,Lin S,Tang Q,Yan Z

Mon Nov 01 00:00:00 UTC 2021

Sunitinib malate inhibits intestinal tumor development in male Apc^Min/+ mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3.

International immunopharmacology

Chen L,Xu P,Xiao Q,Chen L,Li S,Jian JM,Zhong YB

Fri Jan 01 00:00:00 UTC 2021

Whole-Exome Sequencing Reveals New Potential Mutations Genes for Primary Mucosa-Associated Lymphoid Tissue Lymphoma Arising From the Kidney.

Frontiers in oncology

Wen S,Liu T,Zhang H,Zhou X,Jin H,Sun M,Yun Z,Luo H,Ni Z,Zhao R,Fan B

Tue Feb 16 00:00:00 UTC 2021

CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.

Biochemical and biophysical research communications

Sun R,Li H,Li J,Shen S,Cui G,Dong G

Thu Dec 17 00:00:00 UTC 2020

The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.

Frontiers in cell and developmental biology

Chang Z,Huang R,Fu W,Li J,Ji G,Huang J,Shi W,Yin H,Wang W,Meng T,Huang Z,Wei Q,Qin H

Fri Mar 29 00:00:00 UTC 2024

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.

Nature communications

Quach C,Song Y,Guo H,Li S,Maazi H,Fung M,Sands N,O'Connell D,Restrepo-Vassalli S,Chai B,Nemecio D,Punj V,Akbari O,Idos GE,Mumenthaler SM,Wu N,Martin SE,Hagiya A,Hicks J,Cui H,Liang C

Thu Dec 12 00:00:00 UTC 2019

Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.

Veterinary microbiology

Guo F,Yu X,Xu A,Xu J,Wang Q,Guo Y,Wu X,Tang Y,Ding Z,Zhang Y,Gong T,Pan Z,Li S,Kong L

Sun Jul 01 00:00:00 UTC 2018

Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.

Veterinary microbiology

Guo F,Yu X,Xu A,Xu J,Wang Q,Guo Y,Wu X,Tang Y,Ding Z,Zhang Y,Gong T,Pan Z,Li S,Kong L

Sun Jul 01 00:00:00 UTC 2018

Steroid receptor coactivator-3 is a pivotal target of gambogic acid in B-cell Non-Hodgkin lymphoma and an inducer of histone H3 deacetylation.

European journal of pharmacology

Zhao Z,Zhang X,Wen L,Yi S,Hu J,Ruan J,Zhao F,Cui G,Fang J,Chen Y

Sat Oct 15 00:00:00 UTC 2016

Steroid receptor coactivator-3 is a pivotal target of gambogic acid in B-cell Non-Hodgkin lymphoma and an inducer of histone H3 deacetylation.

European journal of pharmacology

Zhao Z,Zhang X,Wen L,Yi S,Hu J,Ruan J,Zhao F,Cui G,Fang J,Chen Y

Sat Oct 15 00:00:00 UTC 2016

Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine.

Scientific reports

Shi Y,Xu LZ,Peng K,Wu W,Wu R,Liu ZQ,Yang G,Geng XR,Liu J,Liu ZG,Liu Z,Yang PC

Wed Dec 02 00:00:00 UTC 2015

Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine.

Scientific reports

Shi Y,Xu LZ,Peng K,Wu W,Wu R,Liu ZQ,Yang G,Geng XR,Liu J,Liu ZG,Liu Z,Yang PC

Wed Dec 02 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

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Gene Aliases: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

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UniProt ID: (Human) P41182

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Entrez Gene ID: (Human) 604

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding chromatin DNA binding sequence-specific DNA binding metal ion binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BCL6 Polyclonal Antibody

BCL6 Antibody (21187-1-AP) in IHC (P)

Product Details

21187-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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