Invitrogen

BCL6 Polyclonal Antibody

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1 Published Figure
2 References
View all (100) BCL6 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-27390

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Immunoprecipitation (IP)

1:100-1:500
-

ChIP assay (ChIP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human BCL6. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544866

Product Specific Information

Recommended positive controls: Jurkat, K562, THP-1, Neuro2A, GL261, C8D30, NIH-3T3, Raw264.7, C2C12.

Predicted reactivity: Mouse (91%), Rat (91%), Dog (90%), Pig (89%), Rhesus Monkey (97%), Bovine (90%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

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Gene Aliases: Bcl-6; BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

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UniProt ID: (Human) P41182, (Mouse) P41183

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Entrez Gene ID: (Human) 604, (Rat) 303836, (Mouse) 12053

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding chromatin DNA binding sequence-specific DNA binding metal ion binding molecular_function DNA binding nucleic acid binding
Process(es)
protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter cell morphogenesis negative regulation of cell-matrix adhesion germinal center formation negative regulation of type 2 immune response regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular response to DNA damage stimulus Rho protein signal transduction spermatogenesis protein localization biological_process negative regulation of cell proliferation actin cytoskeleton organization B cell differentiation negative regulation of cell growth positive regulation of B cell proliferation positive regulation of histone deacetylation negative regulation of mast cell cytokine production negative regulation of Rho protein signal transduction type 2 immune response regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process regulation of memory T cell differentiation negative regulation of cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated negative regulation of isotype switching to IgE isotypes erythrocyte development regulation of inflammatory response positive regulation of cellular component movement negative regulation of cellular senescence regulation of germinal center formation negative regulation of B cell apoptotic process transcription, DNA-templated inflammatory response myeloid cell differentiation regulation of apoptotic process regulation of GTPase activity regulation of neurogenesis regulation of immune response immune system process regulation of transcription, DNA-templated
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