Proteintech

BCO2 Polyclonal Antibody

BCO2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BCO2 Antibody (14324-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human prostate hyperplasia tissue slide using (Product # 14324-1-AP) (BCO2 antibody) at dilution of 1:200 (under 10x lens).

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Product Details

14324-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BCO2 Fusion Protein Ag5590 (209-556 aa encoded by BC041656)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody detects the N-terminal of BCO2.

Immunogen sequence: ERFMSRFEL PGKAAGFSYK VIRVPPEKVD LGETIHGVQV ICSIASTEKG KPSYYHSFGM TRNYIIFIEQ PLKMNLWKIA TSKIRGKAFS DGISWEPQCN TRFHVVEKRT GQLLPGRYYS KPFVTFHQIN AFEDQGCVII DLCCQDNGRT LEVYQLQNLR KAGEGLDQVH NSAAKSFPRR FVLPLNVSLN APEGDNLSPL SYTSASAVKQ ADGTIWCSHE NLHQEDLEKE GGIEFPQIYY DRFSGKKYHF FYGCGFRHLV GDSLIKVDVV NKTLKVWRED GFYPSEPVFV PAPGTNEEDG GVILSVVITP NQNESNFLLV LDAKNFEELG RAEVPVQMPY GFHGTFIPI (209-556 aa encoded by BC041656)

Target Information

BCDO2 catalyzes the asymmetric oxidative cleavage of beta-carotene in carotene metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms.

Molecules (Basel, Switzerland)

Gong X,Smith JR,Swanson HM,Rubin LP

Sat Apr 14 00:00:00 UTC 2018

Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.

The Journal of nutritional biochemistry

Guo X,Wu L,Lyu Y,Chowanadisai W,Clarke SL,Lucas EA,Smith BJ,He H,Wang W,Medeiros DM,Lin D

Tue Aug 01 00:00:00 UTC 2017

Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.

The Journal of nutritional biochemistry

Guo X,Wu L,Lyu Y,Chowanadisai W,Clarke SL,Lucas EA,Smith BJ,He H,Wang W,Medeiros DM,Lin D

Tue Aug 01 00:00:00 UTC 2017

Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.

Proceedings of the National Academy of Sciences of the United States of America

Li B,Vachali PP,Gorusupudi A,Shen Z,Sharifzadeh H,Besch BM,Nelson K,Horvath MM,Frederick JM,Baehr W,Bernstein PS

Tue Jul 15 00:00:00 UTC 2014

Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.

Proceedings of the National Academy of Sciences of the United States of America

Li B,Vachali PP,Gorusupudi A,Shen Z,Sharifzadeh H,Besch BM,Nelson K,Horvath MM,Frederick JM,Baehr W,Bernstein PS

Tue Jul 15 00:00:00 UTC 2014

Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.

Proceedings of the National Academy of Sciences of the United States of America

Li B,Vachali PP,Gorusupudi A,Shen Z,Sharifzadeh H,Besch BM,Nelson K,Horvath MM,Frederick JM,Baehr W,Bernstein PS

Tue Jul 15 00:00:00 UTC 2014

Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.

Proceedings of the National Academy of Sciences of the United States of America

Li B,Vachali PP,Gorusupudi A,Shen Z,Sharifzadeh H,Besch BM,Nelson K,Horvath MM,Frederick JM,Baehr W,Bernstein PS

Tue Jul 15 00:00:00 UTC 2014

Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.

Molecular nutrition & food research

Lin D,He H,Ji H,Willis J,Willard L,Jiang Y,Medeiros DM,Wark L,Han J,Liu Y,Lu B

Thu May 01 00:00:00 UTC 2014

Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.

Molecular nutrition & food research

Lin D,He H,Ji H,Willis J,Willard L,Jiang Y,Medeiros DM,Wark L,Han J,Liu Y,Lu B

Thu May 01 00:00:00 UTC 2014

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.

Molecular nutrition & food research

Yu H,Wark L,Ji H,Willard L,Jaing Y,Han J,He H,Ortiz E,Zhang Y,Medeiros DM,Lin D

Mon Jul 01 00:00:00 UTC 2013

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.

Molecular nutrition & food research

Yu H,Wark L,Ji H,Willard L,Jaing Y,Han J,He H,Ortiz E,Zhang Y,Medeiros DM,Lin D

Mon Jul 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: b,b-carotene-9',10'-dioxygenase; B-diox-II; beta,beta-carotene 9',10'-dioxygenase variant 1; beta,beta-carotene 9',10'-dioxygenase variant 2; beta,beta-carotene 9',10'-dioxygenase variant 3; Beta,beta-carotene 9',10'-oxygenase; beta-carotene 9', 10'-dioxygenase 2; beta-carotene 9',10' oxygenase; beta-carotene 9',10'-dioxygenase 2; Beta-carotene dioxygenase 2; beta-diox-II; carotenoid 9',10' monooxygenase II; carotenoid 9',10' monoxygenase II; carotenoid-9',10'-cleaving dioxygenase; Carotenoid-cleaving dioxygenase, mitochondrial

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Gene Aliases: Ab2-079; B-DIOX-II; BCDO2; Bcmo2; BCO2; CMO2

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UniProt ID: (Human) Q9BYV7, (Mouse) Q99NF1

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Entrez Gene ID: (Human) 83875, (Rat) 315644, (Mouse) 170752

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Function(s)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen metal ion binding structural constituent of ribosome oxidoreductase activity dioxygenase activity

Process(es)

translation carotenoid metabolic process carotene metabolic process carotene catabolic process regulation of mitochondrial membrane potential oxidation-reduction process regulation of reactive oxygen species metabolic process retinoid metabolic process xanthophyll metabolic process retinoic acid metabolic process retinal metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BCO2 Polyclonal Antibody

BCO2 Antibody (14324-1-AP) in IHC (P)

Product Details

14324-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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