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BCOR Polyclonal Antibody

BCOR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BCOR Antibody (12107-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12107-1-AP (BCOR antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

12107-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

View 1 publication 1 publication

ChIP assay (ChIP)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BCOR Fusion Protein Ag2752 (2-361 aa encoded by BC009675)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RFRKRPEPS SDYDLSPAKQ EPKPFDRLQQ LLPASQSTQL PCSSSPQETT QSRPMPPEAR RLIVNKNAGE TLLQRAARLG YEEVVLYCLE NKICDVNHRD NAGYCALHEA CARGWLNIVR HLLEYGADVN CSAQDGTRPL HDAVENDHLE IVRLLLSYGA DPTLATYSGR TIMKMTHSEL MEKFLTDYLN DLQGRNDDDA SGTWDFYGSS VCEPDDESGY DVLANPPGPE DQDDDDDAYS DVFEFEFSET PLLPCYNIQV SVAQGPRNWL LLSDVLKKLK MSSRIFRCNF PNVEIVTIAE AEFYRQVSAS LLFSCSKDLE AFNPESKELL DLVEFTNEIQ TLLGSSVEWL HPSDLASDNY W (2-361 aa encoded by BC009675)

Target Information

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes.

Blood cancer discovery

Schaefer EJ,Wang HC,Karp HQ,Meyer CA,Cejas P,Gearhart MD,Adelman ER,Fares I,Apffel A,Lim K,Xie Y,Gibson CJ,Schenone M,Murdock HM,Wang ES,Gondek LP,Carroll MP,Vedula RS,Winer ES,Garcia JS,Stone RM,Luskin MR,Carr SA,Long HW,Bardwell VJ,Figueroa ME,Lindsley RC

Tue Mar 01 00:00:00 UTC 2022

BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes.

Blood cancer discovery

Tue Mar 01 00:00:00 UTC 2022

BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes.

Blood cancer discovery

Tue Mar 01 00:00:00 UTC 2022

PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.

Nature communications

Takano J,Ito S,Dong Y,Sharif J,Nakajima-Takagi Y,Umeyama T,Han YW,Isono K,Kondo T,Iizuka Y,Miyai T,Koseki Y,Ikegaya M,Sakihara M,Nakayama M,Ohara O,Hasegawa Y,Hashimoto K,Arner E,Klose RJ,Iwama A,Koseki H,Ikawa T

Mon Nov 28 00:00:00 UTC 2022

PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.

Nature communications

Mon Nov 28 00:00:00 UTC 2022

Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.

Nucleic acids research

Su D,Wang W,Hou Y,Wang L,Yi X,Cao C,Wang Y,Gao H,Wang Y,Yang C,Liu B,Chen X,Wu X,Wu J,Yan D,Wei S,Han L,Liu S,Wang Q,Shi L,Shan L

Fri May 07 00:00:00 UTC 2021

BCOR Internal Tandem Duplication Expression in Neural Stem Cells Promotes Growth, Invasion, and Expression of PRC2 Targets.

International journal of molecular sciences

Nakata S,Yuan M,Rubens JA,Kahlert UD,Maciaczyk J,Raabe EH,Eberhart CG

Sat Apr 10 00:00:00 UTC 2021

Secreted frizzled-related protein 2 promotes the osteo/odontogenic differentiation and paracrine potentials of stem cells from apical papilla under inflammation and hypoxia conditions.

Cell proliferation

Yang H,Li G,Han N,Zhang X,Cao Y,Cao Y,Fan Z

Wed Jan 01 00:00:00 UTC 2020

DICER1 screening in 15 paediatric paratesticular sarcomas unveils an unusual DICER1-associated sarcoma.

The journal of pathology. Clinical research

Apellaniz-Ruiz M,Cullinan N,Grant R,Marrano P,Priest JR,Thorner PS,Goudie C,Foulkes WD

Wed Jul 01 00:00:00 UTC 2020

Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel).

Journal of clinical pathology

Loke BN,Lee VKM,Sudhanshi J,Wong MK,Kuick CH,Puhaindran M,Chang KTE

Tue Aug 01 00:00:00 UTC 2017

Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel).

Journal of clinical pathology

Loke BN,Lee VKM,Sudhanshi J,Wong MK,Kuick CH,Puhaindran M,Chang KTE

Tue Aug 01 00:00:00 UTC 2017

Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.

Scientific reports

Yan Y,Zhao W,Huang Y,Tong H,Xia Y,Jiang Q,Qin J

Mon Apr 10 00:00:00 UTC 2017

Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.

Scientific reports

Yan Y,Zhao W,Huang Y,Tong H,Xia Y,Jiang Q,Qin J

Mon Apr 10 00:00:00 UTC 2017

Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney.

Nature genetics

Ueno-Yokohata H,Okita H,Nakasato K,Akimoto S,Hata J,Koshinaga T,Fukuzawa M,Kiyokawa N

Sat Aug 01 00:00:00 UTC 2015

Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney.

Nature genetics

Ueno-Yokohata H,Okita H,Nakasato K,Akimoto S,Hata J,Koshinaga T,Fukuzawa M,Kiyokawa N

Sat Aug 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: BCL-6 corepressor; BCL-6 interacting corepressor; Bcl6 interacting corepressor; BCoR

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Gene Aliases: 5830466J11Rik; 8430401K06Rik; ANOP2; BCOR; BcorR; D930024N20Rik; KIAA1575; MAA2; MCOPS2; mKIAA1575; RGD1562735

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UniProt ID: (Human) Q6W2J9, (Mouse) Q8CGN4

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Entrez Gene ID: (Human) 54880, (Rat) 317346, (Mouse) 71458

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Function(s)

transcription corepressor activity ubiquitin-protein transferase activity protein binding transcription factor binding heat shock protein binding histone deacetylase binding transcription regulatory region DNA binding molecular_function

Process(es)

negative regulation of transcription from RNA polymerase II promoter negative regulation of histone H3-K36 methylation heart development biological_process negative regulation of bone mineralization histone H2A monoubiquitination odontogenesis negative regulation of transcription, DNA-templated negative regulation of histone H3-K4 methylation palate development specification of axis polarity negative regulation of tooth mineralization negative regulation of nucleic acid-templated transcription transcription, DNA-templated regulation of transcription, DNA-templated chromatin modification

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BCOR Polyclonal Antibody

BCOR Antibody (12107-1-AP) in IHC (P)

Product Details

12107-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

ChIP assay (ChIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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