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Invitrogen
BCOR Polyclonal Antibody
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Product Details
PA5-50919
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the Internal region of human BCoR.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2636367
Product Specific Information
BCOR Polyclonal Antibody detects endogenous levels of BCOR protein.
Target Information
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCL-6 corepressor; BCL-6 interacting corepressor; BCoR
Gene Aliases: 5830466J11Rik; 8430401K06Rik; ANOP2; BCOR; BcorR; D930024N20Rik; KIAA1575; MAA2; MCOPS2; mKIAA1575
UniProt ID: (Human) Q6W2J9, (Mouse) Q8CGN4
Entrez Gene ID: (Human) 54880, (Mouse) 71458
negative regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K36 methylation
transcription, DNA-templated
heart development
negative regulation of bone mineralization
histone H2A monoubiquitination
odontogenesis
negative regulation of transcription, DNA-templated
negative regulation of histone H3-K4 methylation
palate development
specification of axis polarity
negative regulation of tooth mineralization
regulation of transcription, DNA-templated
chromatin modification
negative regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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