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Product Details
BS-9551R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BEND2/CXorf56.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The BEND2 gene, located on chromosome Xp22.2, encodes a protein that is part of the BEN domain-containing family, which is implicated in chromatin organization and transcriptional regulation. BEND2 is critical in spermatogenesis, particularly in the meiotic phase of germ cell development. Knockout studies in male mice have shown that loss of BEND2 disrupts the transition from zygonema to pachynema, interferes with chromosomal synapsis, and impairs the repair of DNA double-strand breaks, ultimately causing infertility. Additionally, BEND2’s interaction with chromatin-associated proteins suggests its role in the formation of transcription-repressor complexes, essential for proper gene expression regulation during meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BEN domain-containing protein 2
Gene Aliases: BEND2; CXorf20
UniProt ID: (Human) Q8NDZ0
Entrez Gene ID: (Human) 139105
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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