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This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon.
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Protein Aliases: Best4-PB; bestrophin 4; Bestrophin-4; CG7259-PB; vitelliform macular dystrophy 2-like 2; Vitelliform macular dystrophy 2-like protein 2
Gene Aliases: BEST4; CG7259; CT22395; dBest4; Dmel\CG7259; Dmel_CG7259; VMD2L2
UniProt ID: (Human) Q8NFU0
Entrez Gene ID: (Human) 266675, (Fruit fly) 39660
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