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Product Details
OSB00008W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 2-40 of mouse BEX1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat.
Specificity of this antibody: BEX1 and BEX2.
Target Information
BEX1/BEX2 belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. BEX1/BEX2 has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brain expressed gene 1; Brain-expressed X-linked protein 1 homolog; Brain-expressed X-linked protein 2 homolog; EG2RVC; expression gene 2 in rat visual cortex; Protein BEX1; Protein BEX2; protein hBex2; reduced expression 3; Reduced expression protein 3; REX-3
Gene Aliases: AA407839; AL024066; AU018692; Bex1; Bex2; Bex4; EG2RVC; Rex3
UniProt ID: (Mouse) Q9R224, (Rat) Q3MKQ2, (Rat) Q3MKQ1, (Mouse) Q9WTZ8
Entrez Gene ID: (Mouse) 19716, (Rat) 501625, (Rat) 363498, (Mouse) 12069
positive regulation of neuroblast proliferation
multicellular organism development
nervous system development
cell differentiation
negative regulation of neuron differentiation
neurotrophin TRK receptor signaling pathway
apoptotic process
regulation of apoptotic process
regulation of cell cycle
cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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