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Invitrogen
BFAR Polyclonal Antibody
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Product Details
PA5-96998
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human BFAR (NP_0576451)
Conjugate
Form
Liquid
Concentration
2.28 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808800
Product Specific Information
Immunogen sequence: MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ KYGNDQIPLA PNTGRANQQM; Positive Samples: HepG2, SKOV3, A-549, SH-SY5Y, SW480, Mouse brain, Mouse heart, Mouse liver, Rat heart; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
Target Information
The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bifunctional apoptosis inhibitor; Bifunctional apoptosis regulator; RING finger protein 47
Gene Aliases: 3010001A07Rik; AI666707; AW107665; BAR; BFAR; RNF47
UniProt ID: (Human) Q9NZS9, (Rat) Q5PQN2, (Mouse) Q8R079
Entrez Gene ID: (Human) 51283, (Rat) 304709, (Mouse) 67118
protein polyubiquitination
apoptotic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
negative regulation of IRE1-mediated unfolded protein response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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