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Bethyl Laboratories
BICD1 Polyclonal Antibody
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BICD1 Antibody (A303-334A) in IP
Detection of human BICD1 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-BICD1 antibody (Product # A303-334A) used for IP at 6 µg/mg lysate. BICD1 was also immunoprecipitated by rabbit anti-BICD1 antibody A303-335A, which recognizes a downstream epitope. For blotting immunoprecipitated BICD1, A303-335A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A303-334A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 300 and 350 of human Bicaudal D Homolog 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bic-D 1; bicaudal D homolog 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bicaudal D homolog 1
Gene Aliases: BICD; BICD1
UniProt ID: (Human) Q96G01
Entrez Gene ID: (Human) 636
RNA processing
intracellular mRNA localization
anatomical structure morphogenesis
viral process
protein localization to organelle
stress granule assembly
positive regulation of receptor-mediated endocytosis
minus-end-directed organelle transport along microtubule
microtubule anchoring at microtubule organizing center
negative regulation of phospholipase C activity
regulation of proteinase activated receptor activity
negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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