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Invitrogen
BICD1 Polyclonal Antibody
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Product Details
PA5-59508
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BICD1. Recombinant protein control fragment (Product #RP-97780).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638552
Product Specific Information
Immunogen sequence: YRQSRVTRSG SLKGPDDPRG LLSPRLARRG VSSPVETRTS SEPVAKESTE ASKEPSPTKT PTISPVITAP PSSPVLDTSD IRKE
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bic-D 1; bicaudal D homolog 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bicaudal D homolog 1
Gene Aliases: BICD; BICD1
UniProt ID: (Human) Q96G01
Entrez Gene ID: (Human) 636
RNA processing
intracellular mRNA localization
anatomical structure morphogenesis
viral process
protein localization to organelle
stress granule assembly
positive regulation of receptor-mediated endocytosis
minus-end-directed organelle transport along microtubule
microtubule anchoring at microtubule organizing center
negative regulation of phospholipase C activity
regulation of proteinase activated receptor activity
negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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