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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • cIAP2 Antibodies

          OriGene

          BIRC3 Monoclonal Antibody (OTI3G4), TrueMAB™

          View all (34) cIAP2 antibodies
          Datasheet
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          Datasheet
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          Cite BIRC3 Monoclonal Antibody (OTI3G4), TrueMAB™

          • Antibody Testing Data (3)
          BIRC3 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          BIRC3 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          BIRC3 Antibody (CF800063) in WB

          Western blot analysis of extracts (35 µg) from 9 different cell lines by using anti-BIRC3 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          BIRC3 Antibody in Western Blot (WB)
          BIRC3 Antibody in Western Blot (WB)
          BIRC3 Antibody in Flow Cytometry (Flow)

          Product Details

          CF800063

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Flow Cytometry (Flow)

          1:100
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          OTI3G4

          Immunogen

          Human recombinant protein fragment corresponding to amino acids 255-529 of human BIRC3 produced in E.coli.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Concentration

          1 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 8% trehalose

          Contains

          no preservative

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

          Target Information

          The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
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          Cite this product

          Bioinformatics

          Protein Aliases: AIP 2; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1

          View more View less

          Gene Aliases: AIP1; API2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49

          View more View less

          UniProt ID: (Human) Q13489

          View more View less

          Entrez Gene ID: (Human) 330

          View more View less

          Function(s)
          ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process
          Process(es)
          apoptotic process cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling spermatogenesis regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein ubiquitination positive regulation of protein ubiquitination tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of innate immune response regulation of inflammatory response protein heterooligomerization regulation of necroptotic process negative regulation of necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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