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Product Details
H00112401-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BIRC8 (AAH39318.1, 1 a.a. approximately 236 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK PKEDPWEQHA KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS LTKRISDTIF PNPMLQEAIR MGFDFKDVKK IMEERIQTSG SNYKTLGVLV ADLVSAQKDT TENELNQTSL QREISPEEPL RRLQEEKLCK ICMDRHIAVV FIPCGHLVTC KQCAEAVDRC PMCSMVIDFK QRVFMS
Target Information
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: baculoviral IAP repeat-containing 8; IAP-like protein 2; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis
Gene Aliases: hILP2; ILP-2; ILP2
Entrez Gene ID: (Human) 112401
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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