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Invitrogen
BMP-3 Polyclonal Antibody
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BMP-3 Antibody (PA5-99399) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded BMP-3 in human liver cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with BMP-3 polyclonal antibody (Product # PA5-99399) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-99399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BMP3(Accession P12645), corresponding to amino acid residues R286-K336.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2818332
Product Specific Information
Antibody detects endogenous levels of total BMP3.
Target Information
The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage development, BMPs regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. BMPs also play a role in dorsal/ventral patterning. BMP3, highly expressed in lung, ovary and small intestine, participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-3; BMP-3A; Bone morphogenetic protein; Bone morphogenetic protein 3; bone morphogenetic protein 3 (osteogenic); Bone morphogenetic protein 3A; bone morphogenetic protein-3; Osteogenin
Gene Aliases: 9130206H07; 9530029I04Rik; Bmp-3; BMP-3A; BMP3; BMP3A; PBMP3
UniProt ID: (Human) P12645, (Rat) P49002, (Mouse) Q8BHE5
Entrez Gene ID: (Human) 651, (Rat) 25667, (Mouse) 110075
ossification
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
cell development
cartilage development
SMAD protein signal transduction
skeletal system development
osteoblast differentiation
cell-cell signaling
BMP signaling pathway
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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