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Invitrogen
BMP-5 Polyclonal Antibody
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BMP-5 Antibody (PA5-104248) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded BMP-5 in human liver tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with BMP-5 polyclonal antibody (Product # PA5-104248) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-104248
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BMP5(Accession P22003), corresponding to amino acid residues A143-V193.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2853564
Product Specific Information
Antibody detects endogenous levels of total BMP5.
Target Information
RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 5; BMP-5; bone morphogenenic protein-5; Bone morphogenetic protein; Bone morphogenetic protein 5; MGC34244; short ear
Gene Aliases: AU023399; Bmp-5; BMP5; se
UniProt ID: (Human) P22003, (Mouse) P49003
Entrez Gene ID: (Human) 653, (Mouse) 12160
skeletal system development
ossification
type B pancreatic cell development
multicellular organism development
pattern specification process
negative regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
cell differentiation
BMP signaling pathway
male genitalia development
negative regulation of aldosterone biosynthetic process
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
cell development
positive regulation of epithelial cell proliferation
cartilage development
SMAD protein signal transduction
positive regulation of dendrite development
negative regulation of cortisol biosynthetic process
positive regulation of DNA-dependent DNA replication
negative regulation of epithelial to mesenchymal transition
negative regulation of mononuclear cell migration
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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