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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • BMP4 Antibodies

          Invitrogen

          BMP4 Recombinant Rabbit Monoclonal Antibody (7M10V7)

          View all (29) BMP4 antibodies

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          Cite BMP4 Recombinant Rabbit Monoclonal Antibody (7M10V7)

          • Antibody Testing Data (2)
          BMP4 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          BMP4 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          BMP4 Antibody (MA5-55252) in WB

          Western Blot analysis of various lysates using BMP4 Recombinant Monoclonal Antibody (Product # MA5-55252) at 1:1,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Negative control (NC): U-937 Exposure time: 90s. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          BMP4 Antibody in Western Blot (WB)
          BMP4 Antibody in Western Blot (WB)

          Product Details

          MA5-55252

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          ELISA (ELISA)

          1 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          7M10V7

          Immunogen

          A synthetic peptide corresponding to a sequence within amino acids 250-350 of human BMP4.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.3, with 0.05% BSA, 50% glycerol

          Contains

          0.05% ProClin 300

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          RRID

          AB_3667494

          Product Specific Information

          Immunogen Sequence: QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHALTRRRR AKRSPKHHSQ RARKKNKNCR RHSLYVDFSD VGWNDWIVAP PGYQAFYCHG DCPFPLADHL N

          Target Information

          The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: BMP; BMP-2B; BMP-4; Bone morphogenetic protein; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein

          View more View less

          Gene Aliases: Bmp-4; BMP2B; Bmp2b-1; BMP2B1; BMP4; BOMPR4A; Dvr-4; DVR4; MCOPS6; OFC11; ZYME

          View more View less

          UniProt ID: (Human) P12644, (Mouse) P21275

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          Entrez Gene ID: (Human) 652, (Mouse) 12159, (Rat) 25296

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          Function(s)
          cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding co-receptor binding chemoattractant activity protein homodimerization activity BMP receptor binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity skeletal system development ossification angiogenesis ovarian follicle development blood vessel development osteoblast differentiation eye development metanephros development ureteric bud development branching involved in ureteric bud morphogenesis mesoderm formation organ induction kidney development neural tube closure positive regulation of protein phosphorylation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation vasculature development endochondral ossification blood vessel endothelial cell proliferation involved in sprouting angiogenesis chondrocyte differentiation hematopoietic progenitor cell differentiation lymphoid progenitor cell differentiation renal system process BMP signaling pathway involved in heart induction secondary heart field specification type B pancreatic cell development mesenchymal to epithelial transition involved in metanephros morphogenesis common-partner SMAD protein phosphorylation multicellular organism development germ cell development mesodermal cell fate determination heart development positive regulation of cell proliferation negative regulation of cell proliferation post-embryonic development tissue development anterior/posterior axis specification specification of organ position regulation of cell fate commitment regulation of gene expression positive regulation of calcium ion transport into cytosol positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cell death positive regulation of neuron projection development telencephalon development dorsal/ventral neural tube patterning telencephalon regionalization pituitary gland development cell differentiation erythrocyte differentiation monocyte differentiation macrophage differentiation lung development embryonic limb morphogenesis positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway forebrain development positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein binding negative regulation of chondrocyte differentiation positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus protein localization to nucleus cellular response to oxidative stress embryonic hindlimb morphogenesis tendon cell differentiation deltoid tuberosity development growth regulation of protein import into nucleus negative regulation of phosphorylation odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis of dentin-containing tooth embryonic digit morphogenesis camera-type eye development positive regulation of apoptotic process negative regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity cell fate commitment regulation of cell differentiation positive regulation of cell differentiation positive regulation of endothelial cell differentiation positive regulation of epidermal cell differentiation negative regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development mesodermal cell differentiation intermediate mesodermal cell differentiation camera-type eye morphogenesis embryonic morphogenesis anatomical structure formation involved in morphogenesis regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation neuron fate commitment embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis embryonic skeletal system development negative regulation of oligodendrocyte differentiation smooth muscle tissue development branching morphogenesis of an epithelial tube positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive chemotaxis smooth muscle cell differentiation regulation of smooth muscle cell differentiation cartilage development cardiac muscle cell differentiation positive regulation of cardiac muscle fiber development inner ear receptor cell differentiation lens induction in camera-type eye embryonic skeletal joint morphogenesis bone development cranial suture morphogenesis positive regulation of SMAD protein import into nucleus regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction lung morphogenesis epithelium development bronchus development trachea development trachea formation epithelial tube branching involved in lung morphogenesis branching involved in prostate gland morphogenesis bud elongation involved in lung branching epithelial cell proliferation involved in lung morphogenesis bud dilation involved in lung branching prostate gland morphogenesis negative regulation of cell death mammary gland formation epithelial-mesenchymal cell signaling negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis regulation of morphogenesis of a branching structure regulation of cartilage development positive regulation of cartilage development positive regulation of branching involved in lung morphogenesis BMP signaling pathway involved in ureter morphogenesis BMP signaling pathway involved in renal system segmentation pulmonary artery endothelial tube morphogenesis negative regulation of thymocyte apoptotic process positive regulation of hepatocyte differentiation regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to dexamethasone stimulus BMP signaling pathway involved in nephric duct formation renal system development negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway glomerular capillary formation negative regulation of glomerular mesangial cell proliferation mesenchymal cell differentiation involved in kidney development ureter epithelial cell differentiation ureter smooth muscle cell differentiation negative regulation of mesenchymal cell proliferation involved in ureter development metanephric collecting duct development positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of glomerulus development positive regulation of store-operated calcium channel activity positive regulation of mesenchymal stem cell proliferation negative regulation of metanephric S-shaped body morphogenesis negative regulation of metanephric comma-shaped body morphogenesis positive regulation of DNA-dependent DNA replication negative regulation of cell proliferation involved in heart morphogenesis positive regulation of endothelial cell apoptotic process mesenchymal cell differentiation involved in renal system development mesonephros development outflow tract septum morphogenesis membranous septum morphogenesis muscular septum morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation cardiac right ventricle morphogenesis apoptotic process involved in endocardial cushion morphogenesis cardiac septum development smoothened signaling pathway response to estradiol response to retinoic acid response to testosterone wound healing tongue morphogenesis response to glucocorticoid anatomical structure regression retina development in camera-type eye cloacal septation lung lobe development coronary vasculature development BMP signaling pathway involved in heart development pharyngeal arch artery morphogenesis cellular response to mechanical stimulus response to nitric oxide cellular response to BMP stimulus glomerular visceral epithelial cell development mesenchymal cell proliferation involved in ureteric bud development mesenchymal cell proliferation involved in ureter development cellular response to thyroid hormone stimulus positive regulation of cell proliferation involved in outflow tract morphogenesis cardiac jelly development negative regulation of extrinsic apoptotic signaling pathway brain development mesoderm development cell proliferation response to mechanical stimulus response to organic cyclic compound
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