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Proteintech
BMP5 Monoclonal Antibody (1G6C10)
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Product Details
66370-1-IG
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G6C10
Immunogen
BMP5 Fusion Protein Ag3952 (28-348 aa encoded by BC027958)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GLGDNHVHS SFIYRRLRNH ERREIQREIL SILGLPHRPR PFSPGKQASS APLFMLDLYN AMTNEENPEE SEYSVRASLA EETRGARKGY PASPNGYPRR IQLSRTTPLT TQSPPLASLH DTNFLNDADM VMSFVNLVER DKDFSHQRRH YKEFRFDLTQ IPHGEAVTAA EFRIYKDRSN NRFENETIKI SIYQIIKEYT NRDADLFLLD TRKAQALDVG WLVFDITVTS NHWVINPQNN LGLQLCAETG DGRSINVKSA GLVGRQGPQS KQPFMVAFFK ASEVLLRSVR AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SE (28-348 aa encoded by BC027958)
Target Information
RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 5; BMP-5; bone morphogenenic protein-5; Bone morphogenetic protein; Bone morphogenetic protein 5; MGC34244
Gene Aliases: BMP5
UniProt ID: (Human) P22003
Entrez Gene ID: (Human) 653, (Pig) 100151964
skeletal system development
ossification
type B pancreatic cell development
pattern specification process
negative regulation of cell proliferation
negative regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
BMP signaling pathway
male genitalia development
negative regulation of aldosterone biosynthetic process
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
cartilage development
SMAD protein signal transduction
negative regulation of mononuclear cell migration
positive regulation of dendrite development
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cortisol biosynthetic process
positive regulation of DNA-dependent DNA replication
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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