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Abnova
BMP8B Monoclonal Antibody (6D6)
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Product Details
H00000656-M01A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6D6
Immunogen
BMP8B (NP_001711, 274 a.a. approximately 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: KKSNELPQAN RLPGIFDDVH GSHGRQVCRR HELYVSFQDL GWLDWVIAPQ GYSAYYCEGE CSFPLDSCMN ATNHAILQSL VHLMMPDAV
Target Information
BMP-8B encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. BMP-8B may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-8; BMP-8B; Bone morphogenetic protein; bone morphogenetic protein 8 (osteogenic protein 2); Bone morphogenetic protein 8B; dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); MGC131757; OP-2; Osteogenic protein 2
Gene Aliases: BMP8; BMP8B; OP2
UniProt ID: (Human) P34820
Entrez Gene ID: (Human) 656
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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