Invitrogen

BMPR1A Polyclonal Antibody

BMPR1A Antibody in Immunocytochemistry (ICC/IF)

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BMPR1A Antibody (38-6000) in ICC/IF

Immunofluorescent analysis of BMPR1A /CD292 was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with BMPR1A /CD292 Rabbit Polyclonal Antibody (Product # 38-6000) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conju... View More

BMPR1A Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

BMPR1A Antibody in Immunohistochemistry (IHC)

BMPR1A Antibody in Immunoprecipitation (IP)

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Product Details

38-6000

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

2 µg/mL

View 2 publications 2 publications

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from an internal region of the human BMPR-1A (bone morphogenetic protein receptor type 1A, Serine/threonine protein kinase receptor R5 (SKR5), activin receptor-like kinase-3 (ALK-3)), which differs from mouse and rat BMPR-1A by one nonconservative amino acid replacement.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2533377

Target Information

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.

Scientific reports

Nyamsuren G,Rapp G,Dihazi H,Zeisberg EM,Tampe D,Tampe B,Zeisberg M

38-6000 was used in Western Blotting to provide additional evidence for the anti-fibrotic activity of ARNT-ARNT homodimers and reveal Ser77 phosphorylation as a novel pharmacological target to realize the therapeutic potential of increased ARNT transactivation activity.

Wed Dec 15 00:00:00 UTC 2021

PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.

Scientific reports

Nyamsuren G,Rapp G,Dihazi H,Zeisberg EM,Tampe D,Tampe B,Zeisberg M

Wed Dec 15 00:00:00 UTC 2021

Galectin-3 modulates postnatal subventricular zone gliogenesis.

Glia

Al-Dalahmah O,Campos Soares L,Nicholson J,Draijer S,Mundim M,Lu VM,Sun B,Tyler T,Adorján I,O'Neill E,Szele FG

38-6000 was used in Western Blotting to identify the necessity of Galectin-3 for gliogenesis and the ability to induce astrogenesis via bone morphogenetic protein signaling when expression is increased.

Sat Feb 01 00:00:00 UTC 2020

Galectin-3 modulates postnatal subventricular zone gliogenesis.

Glia

Al-Dalahmah O,Campos Soares L,Nicholson J,Draijer S,Mundim M,Lu VM,Sun B,Tyler T,Adorján I,O'Neill E,Szele FG

Sat Feb 01 00:00:00 UTC 2020

Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features.

Molecular genetics & genomic medicine

Russell BE,Rigueur D,Weaver KN,Sund K,Basil JS,Hufnagel RB,Prows CA,Oestreich A,Al-Gazali L,Hopkin RJ,Saal HM,Lyons K,Dauber A

38-6000 was used in Western Blot to report on a patient with a homozygous missense variant in BMPR1A causing skeletal abnormalities, growth failure a large atrial septal defect, severe subglottic stenosis, laryngomalacia, facial dysmorphisms, and developmental delays.

Fri Nov 01 00:00:00 UTC 2019

BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair.

Bone research

Guo Y,Yuan Y,Wu L,Ho TV,Jing J,Sugii H,Li J,Han X,Feng J,Guo C,Chai Y

Published figure using BMPR1A polyclonal antibody (Product # 38-6000) in Immunocytochemistry

Tue Sep 29 00:00:00 UTC 2020

BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair.

Bone research

Guo Y,Yuan Y,Wu L,Ho TV,Jing J,Sugii H,Li J,Han X,Feng J,Guo C,Chai Y

Published figure using BMPR1A polyclonal antibody (Product # 38-6000) in Immunocytochemistry

Tue Sep 29 00:00:00 UTC 2020

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.

Disease models & mechanisms

Liu P,Jiang B,Ma J,Lin P,Zhang Y,Shao C,Sun W,Gong Y

38-6000 was used in immunocytochemistry and western blot to characterize knock-in mice to elucidate the function of SLC33A1

Sun Jan 01 00:00:00 UTC 2017

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.

Disease models & mechanisms

Liu P,Jiang B,Ma J,Lin P,Zhang Y,Shao C,Sun W,Gong Y

38-6000 was used in immunocytochemistry and western blot to characterize knock-in mice to elucidate the function of SLC33A1

Sun Jan 01 00:00:00 UTC 2017

Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.

Endocrinology

Townsend KL,Madden CJ,Blaszkiewicz M,McDougall L,Tupone D,Lynes MD,Mishina Y,Yu P,Morrison SF,Tseng YH

38-6000 was used in Western Blotting to demonstrate an important role for hypothalamic bone morphogenetic protein signalling in the regulation of energy balance.

Fri Dec 01 00:00:00 UTC 2017

Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.

Endocrinology

Townsend KL,Madden CJ,Blaszkiewicz M,McDougall L,Tupone D,Lynes MD,Mishina Y,Yu P,Morrison SF,Tseng YH

38-6000 was used in Western Blotting to demonstrate an important role for hypothalamic bone morphogenetic protein signalling in the regulation of energy balance.

Fri Dec 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; Bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5

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Gene Aliases: 10q23del; 1110037I22Rik; ACVRLK3; ALK3; AU045487; Bmpr; BMPR-IA; BMPR1A; CD292; SKR5

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UniProt ID: (Human) P36894, (Rat) Q78EA7, (Mouse) P36895

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Entrez Gene ID: (Human) 657, (Rat) 81507, (Mouse) 12166

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Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity molecular_function transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BMPR1A Polyclonal Antibody

BMPR1A Antibody (38-6000) in ICC/IF

Product Details

38-6000

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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