Proteintech

BMPR2 Polyclonal Antibody

FIGURE: 1 / 4

BMPR2 Antibody (14376-1-AP) in WB

Mouse brain tissue were subjected to SDS PAGE followed by western blot with (Product # 14376-1-AP) BMPR2 antibody at dilution of 1:2,000 incubated at room temperature for 1.5 hours.

BMPR2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14376-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BMPR2 Fusion Protein Ag5752 (172-504 aa encoded by BC052985)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes endogenous levels of total BMPR2 protein, including 115 kDa precursor, 75 kDa mature form and 150 kDa dimer.

Immunogen sequence: YRMLTGDRK QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER MAEL (172-504 aa encoded by B C052985)

Target Information

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway.

BMC complementary medicine and therapies

Chen Y,Rui R,Wang L,Wang H,Zhu B,Cao A

Mon Jun 26 00:00:00 UTC 2023

LncRNA NIPA1-SO confers atherosclerotic protection by suppressing the transmembrane protein NIPA1.

Journal of advanced research

Jiang M,Song Y,Ren MX,He RC,Dong XH,Li XH,Lu ZF,Li S,Wu J,Bei YR,Liu F,Long Y,Wu SG,Liu XH,Wu LM,Yang HL,McVey DG,Dai XY,Ye S,Hu YW

Fri Dec 01 00:00:00 UTC 2023

LncRNA NIPA1-SO confers atherosclerotic protection by suppressing the transmembrane protein NIPA1.

Journal of advanced research

Jiang M,Song Y,Ren MX,He RC,Dong XH,Li XH,Lu ZF,Li S,Wu J,Bei YR,Liu F,Long Y,Wu SG,Liu XH,Wu LM,Yang HL,McVey DG,Dai XY,Ye S,Hu YW

Fri Dec 01 00:00:00 UTC 2023

LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling.

International journal of medical sciences

Mu R,Chen B,Bi B,Yu H,Liu J,Li J,He M,Rong L,Liu B,Liu K,Zhu L,Shi X,Shuai Y,Jin L

Mon Aug 08 00:00:00 UTC 2022

Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway.

Frontiers in pharmacology

Li L,Yin M,Hu L,Tian X,He X,Zhao C,Li Y,Li Q,Li X

Fri Oct 22 00:00:00 UTC 2021

HYAL1 Is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits HFL-1 Fibroblast Proliferation When Upregulated.

BioMed research international

Leng D,Huang X,Yi J,Zhao H,Zhang Y

Thu Dec 17 00:00:00 UTC 2020

AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling.

Experimental gerontology

Deng G,Zhang L,Wang C,Wang S,Xu J,Dong J,Kang Q,Zhai X,Zhao Y,Shan Z

Sun Nov 01 00:00:00 UTC 2020

SPG6 supports development of acute myeloid leukemia by regulating BMPR2-Smad-Bcl-2/Bcl-xl signaling.

Biochemical and biophysical research communications

Chen J,Li C,Zhan R,Yin Y

Mon Jun 18 00:00:00 UTC 2018

SPG6 supports development of acute myeloid leukemia by regulating BMPR2-Smad-Bcl-2/Bcl-xl signaling.

Biochemical and biophysical research communications

Chen J,Li C,Zhan R,Yin Y

Mon Jun 18 00:00:00 UTC 2018

Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells.

BMC genomics

Chen J,Cui X,Qian Z,Li Y,Kang K,Qu J,Li L,Gou D

Thu Oct 06 00:00:00 UTC 2016

Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells.

BMC genomics

Chen J,Cui X,Qian Z,Li Y,Kang K,Qu J,Li L,Gou D

Thu Oct 06 00:00:00 UTC 2016

Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.

Scientific reports

Zeng Y,Liu H,Kang K,Wang Z,Hui G,Zhang X,Zhong J,Peng W,Ramchandran R,Raj JU,Gou D

Mon Jul 13 00:00:00 UTC 2015

Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.

Scientific reports

Zeng Y,Liu H,Kang K,Wang Z,Hui G,Zhang X,Zhong J,Peng W,Ramchandran R,Raj JU,Gou D

Mon Jul 13 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

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Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK

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UniProt ID: (Human) Q13873, (Mouse) O35607

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Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168

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Function(s)

receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding BMP binding metal ion binding BMP receptor activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BMPR2 Polyclonal Antibody

BMPR2 Antibody (14376-1-AP) in WB

Product Details

14376-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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