Invitrogen

BMPR2 Monoclonal Antibody (1F12)

2 Published Figures
2 References
View all (17) BMPR2 antibodies

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Datasheet
Protocols
Questions & Answers

Product Details

MA5-15826

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1F12

Immunogen

Purified recombinant fragment of human BMPR2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153401

Product Specific Information

MA5-15826 targets BMPR2 in indirect ELISA, IHC and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.

The MA5-15826 immunogen is purified recombinant fragment of human BMPR2 expressed in E. Coli.

MA5-15826 detects BMPR2 which has a predicted molecular weight of approximately 115kDa.

Target Information

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

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Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK

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UniProt ID: (Human) Q13873, (Mouse) O35607

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Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168

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Function(s)
receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding BMP binding metal ion binding BMP receptor activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
mesoderm formation maternal placenta development positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure transcription from RNA polymerase II promoter protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway brain development cellular response to starvation anterior/posterior pattern specification positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation regulation of lung blood pressure signal transduction by protein phosphorylation proteoglycan biosynthetic process negative regulation of cell growth positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway regulation of cell proliferation positive regulation of osteoblast differentiation negative regulation of vasoconstriction vascular endothelial growth factor receptor signaling pathway lung alveolus development positive regulation of axon extension involved in axon guidance retina development in camera-type eye limb development endochondral bone morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye negative regulation of chondrocyte proliferation negative regulation of DNA biosynthetic process positive regulation of protein phosphorylation endothelial cell proliferation phosphorylation endothelial cell apoptotic process activin receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter cellular response to BMP stimulus
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