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BNIP3L Polyclonal Antibody

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BNIP3L Antibody (12986-1-AP) in WB

Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12986-1-AP ( BNIP3L Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Product Details

12986-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BNIP3L Fusion Protein Ag3624 (1-219 aa encoded by BC001559)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize both BNIP3 and BNIP3L. BNIP3L has Dimer form with MW ~70 kDa.

Immunogen sequence: MSSHLVEPP PPLHNNNNNC EENEQSLPPP AGLNSSWVEL PMNSSNGNDN GNGKNGGLEH VPSSSSIHNG DMEKILLDAQ HESGQSSSRG SSHCDSPSPQ EDGQIMFDVE MHTSRDHSSQ SEEEVVEGEK EVEALKKSAD WVSDWSSRPE NIPPKEFHFR HPKRSVSLSM RKSGAMKKGG IFSAEFLKVF IPSLFLSHVL ALGLGIYIGK RLSTPSASTY (1-219 aa encoded by BC001559)

Target Information

This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.

Autophagy

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Fri Sep 01 00:00:00 UTC 2023

Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis.

Autophagy

Bai J,Liu T,Tu B,Yuan M,Shu Z,Fan M,Huo S,Guo Y,Wang L,Wang H,Zhao Y

Wed Feb 01 00:00:00 UTC 2023

In Vivo Metabolic Responses to Different Formulations of Amino Acid Mixtures for the Treatment of Phenylketonuria (PKU).

International journal of molecular sciences

Giarratana N,Giardino L,Bighinati A,Reiner G,Rocha JC

Thu Feb 17 00:00:00 UTC 2022

Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes.

Frontiers in cell and developmental biology

Lv X,Zhang R,Xu L,Wang G,Yan C,Lin P

Tue Apr 05 00:00:00 UTC 2022

A novel PHD2 inhibitor acteoside from Cistanche tubulosa induces skeletal muscle mitophagy to improve cancer-related fatigue.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang S,Gong F,Liu J,Liu T,Yang J,Hu J

Wed Jun 01 00:00:00 UTC 2022

Resveratrol Ameliorates Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease via the Autophagy-Lysosome Pathway.

Molecules (Basel, Switzerland)

Bao L,Ye J,Liu N,Shao Y,Li W,Fan X,Zhao D,Wang H,Chen X

Fri Dec 02 00:00:00 UTC 2022

Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.

Free radical biology & medicine

Li Y,Jiang Y,Zhou W,Wu Y,Zhang S,Ding G,Zhang Y,Zhang A,Huang S,Jia Z,You R

Tue Mar 01 00:00:00 UTC 2022

Mitochondrial dysfunction and mitophagy pathway activation in hepatitis E virus-infected livers of Mongolian gerbils.

Virus research

Yang Y,Tian J,Zhang H,Ma M,Li H,Liu T,Yang Y,Liu T,She R

Wed Sep 01 00:00:00 UTC 2021

Mitochondrial dysfunction and mitophagy pathway activation in hepatitis E virus-infected livers of Mongolian gerbils.

Virus research

Yang Y,Tian J,Zhang H,Ma M,Li H,Liu T,Yang Y,Liu T,She R

Wed Sep 01 00:00:00 UTC 2021

Anti-insulin resistance effects of salidroside through mitochondrial quality control.

The Journal of endocrinology

You B,Dun Y,Zhang W,Jiang L,Li H,Xie M,Liu Y,Liu S

Sat Feb 01 00:00:00 UTC 2020

Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice.

Journal of proteome research

Zhang J,Tang N,Zhao Y,Zhao R,Fu X,Zhao D,Zhao Y,Huang L,Li C,Qiu Y,Xue B,Fang L

Fri Apr 03 00:00:00 UTC 2020

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.

Autophagy

Li H,Ham A,Ma TC,Kuo SH,Kanter E,Kim D,Ko HS,Quan Y,Sardi SP,Li A,Arancio O,Kang UJ,Sulzer D,Tang G

Tue Jan 01 00:00:00 UTC 2019

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.

Autophagy

Li H,Ham A,Ma TC,Kuo SH,Kanter E,Kim D,Ko HS,Quan Y,Sardi SP,Li A,Arancio O,Kang UJ,Sulzer D,Tang G

Tue Jan 01 00:00:00 UTC 2019

PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.

Frontiers in pharmacology

Zhao C,He R,Shen M,Zhu F,Wang M,Liu Y,Chen H,Li X,Qin R

Wed Sep 30 00:00:00 UTC 2020

Mitophagy in three cases of immune-mediated necrotizing myopathy associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autoantibodies: ultrastructural and immunohistochemical studies.

Neuromuscular disorders : NMD

Matsubara S,Bokuda K,Asano Y,Morishima R,Sugaya K,Miyamoto K,Koide R,Komori T,Suzuki S,Nishino I

Thu Mar 01 00:00:00 UTC 2018

Mitophagy in three cases of immune-mediated necrotizing myopathy associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autoantibodies: ultrastructural and immunohistochemical studies.

Neuromuscular disorders : NMD

Matsubara S,Bokuda K,Asano Y,Morishima R,Sugaya K,Miyamoto K,Koide R,Komori T,Suzuki S,Nishino I

Thu Mar 01 00:00:00 UTC 2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Cell reports

Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

Tue May 01 00:00:00 UTC 2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Cell reports

Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

Tue May 01 00:00:00 UTC 2018

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.

Journal of cellular and molecular medicine

Liu N,Wu J,Zhang L,Gao Z,Sun Y,Yu M,Zhao Y,Dong S,Lu F,Zhang W

Fri Dec 01 00:00:00 UTC 2017

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.

Journal of cellular and molecular medicine

Liu N,Wu J,Zhang L,Gao Z,Sun Y,Yu M,Zhao Y,Dong S,Lu F,Zhang W

Fri Dec 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19 kDa-interacting protein 3-like; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19kDa interacting protein 3 like; BCL2/adenovirus E1B 19kDa interacting protein 3-like; BCL2/adenovirus E1B 19kDa-interacting protein 3-like; NIP3-like protein X; NIP3L

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Gene Aliases: BNIP3A; BNIP3H; BNIP3L; C86132; D14Ertd719e; Nip3L; NIX

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UniProt ID: (Human) O60238, (Mouse) Q9Z2F7

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Entrez Gene ID: (Human) 665, (Rat) 140923, (Mouse) 12177

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Function(s)

protein binding lamin binding identical protein binding protein homodimerization activity protein heterodimerization activity

Process(es)

mitochondrial protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of programmed cell death defense response to virus mitochondrial outer membrane permeabilization positive regulation of macroautophagy regulation of apoptotic process negative regulation of cell death cellular response to hypoxia regulation of mitophagy regulation of protein targeting to mitochondrion apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BNIP3L Polyclonal Antibody

BNIP3L Antibody (12986-1-AP) in WB

Product Details

12986-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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