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Proteintech
BRAP Polyclonal Antibody
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Product Details
26004-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BRAP Fusion Protein Ag23279 (100-200 aa encoded by BC136698)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AQRSKDHSK ECINAAPDSP SKQLPDQISF FSGNPSVEIV HGIMHLYKTN KMTSLKEDVR RSAMLCILTV PAAMTSHDLM KFVAPFNEVI EQMKIIRDST PN (100-200 aa encoded by BC136698)
Target Information
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRAP; BRAP2; BRCA1-associated protein; galectin-2-binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2
Gene Aliases: BRAP; BRAP2; IMP; RNF52
UniProt ID: (Human) Q7Z569
Entrez Gene ID: (Human) 8315
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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