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Product Details
BS-1210R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BRCA2, amino acids 21-130.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brca 2; brca-2; BRCA1/BRCA2-containing complex, subunit 2; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; Breast cancer type 2 susceptibility protein; Breast cancer type 2 susceptibility protein homolog; FANCB; Fanconi anemia group D1 protein; Fanconi anemia group D1 protein homolog; mutant BRCA2; RP11-298P3.4
Gene Aliases: BRCA2; BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; RAB163; XRCC11
UniProt ID: (Human) P51587, (Mouse) P97929
Entrez Gene ID: (Human) 675, (Mouse) 12190, (Rat) 360254
double-strand break repair via homologous recombination
cytokinesis
oocyte maturation
inner cell mass cell proliferation
DNA repair
nucleotide-excision repair
double-strand break repair
DNA recombination
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle
male meiosis I
spermatogenesis
brain development
cell aging
cell proliferation
female gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
mammary gland development
chromosome breakage
homologous chromosome orientation involved in meiotic metaphase I plate congression
regulation of cytokinesis
negative regulation of mammary gland epithelial cell proliferation
multicellular organism growth
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
chordate embryonic development
histone H3 acetylation
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
replication fork protection
chromosome organization
centrosome duplication
response to nutrient
response to estradiol
telomere maintenance via recombination
DNA synthesis involved in DNA repair
strand displacement
establishment of protein localization to telomere
mitotic recombination-dependent replication fork processing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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