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Bethyl Laboratories
BRD7 Recombinant Rabbit Monoclonal Antibody (BLR220K)
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Product Details
A700-220CF
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR220K
Immunogen
Peptide representing a region between residue 150 and 200 of Human Bromodomain-containing protein 7.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
purified
Storage buffer
BBS, pH 8.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 75 kDa bromodomain protein; bromodomain protein 75 kDa; bromodomain-containing 7; Bromodomain-containing protein 7; Protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein
Gene Aliases: BP75; BRD7; CELTIX1; NAG4; Ptpn13ip
UniProt ID: (Human) Q9NPI1, (Mouse) O88665
Entrez Gene ID: (Human) 29117, (Mouse) 26992
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle
negative regulation of cell proliferation
Wnt signaling pathway
positive regulation of histone acetylation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of G1/S transition of mitotic cell cycle
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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