Invitrogen

BRG1 Recombinant Rabbit Monoclonal Antibody (SN20-03)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-41176

Applications
Tested Dilution
Publications

Western Blot (WB)

1:20,000-1:50,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

Flow Cytometry (Flow)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN20-03

Immunogen

Synthetic peptide within human BRG1 aa 240-280
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898930

Target Information

Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1

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Gene Aliases: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; brg-1; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; RTPS2; SMARCA4; SNF2; SNF2B; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2

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UniProt ID: (Human) P51532, (Mouse) Q3TKT4

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Entrez Gene ID: (Human) 6597, (Mouse) 20586, (Rat) 171379

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription coactivator activity RNA polymerase I CORE element sequence-specific DNA binding p53 binding transcription coactivator activity transcription corepressor activity helicase activity protein binding ATP binding DNA-dependent ATPase activity transcription factor binding Tat protein binding nucleosomal DNA binding protein N-terminus binding androgen receptor binding DNA polymerase binding lysine-acetylated histone binding nucleotide binding RNA polymerase II regulatory region sequence-specific DNA binding DNA binding chromatin binding hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity protein complex binding histone binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis blood vessel development vasculogenesis in utero embryonic development blastocyst growth blastocyst hatching liver development outflow tract morphogenesis nucleosome assembly nucleosome disassembly chromatin remodeling methylation-dependent chromatin silencing transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter nervous system development glial cell fate determination heart development positive regulation of cell proliferation DNA methylation on cytosine within a CG sequence chromatin modification stem cell population maintenance neurogenesis positive regulation of Wnt signaling pathway extracellular matrix organization keratinocyte differentiation negative regulation of cell growth regulation of cell migration forebrain development hindbrain development embryonic hindlimb morphogenesis aortic smooth muscle cell differentiation ATP-dependent chromatin remodeling negative regulation of apoptotic process positive regulation of DNA binding positive regulation by host of viral transcription histone H3 acetylation positive regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic organ morphogenesis epidermis morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity definitive erythrocyte differentiation heart trabecula formation negative regulation of androgen receptor signaling pathway pharyngeal arch artery morphogenesis lens fiber cell development positive regulation of pri-miRNA transcription from RNA polymerase II promoter neural retina development regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter during mitosis spermatid development covalent chromatin modification positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of glucose mediated signaling pathway beta-catenin-TCF complex assembly negative regulation of G1/S transition of mitotic cell cycle
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