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Proteintech
BRK Polyclonal Antibody
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Product Details
18697-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to PTK6.
Target Information
Breast tumor kinase (Brk) is a non-receptor protein tyrosine kinase expressed in over 60% of breast carcinoma tissue samples and breast tumor cell lines. Brk is 80% identity to Sik (Src-related intestinal kinase) and exhibits the features of a novel non-receptor tyrosine kinase, including amino terminal SH3 and SH2 domains. Low levels of Brk transcripts have been identified in some human breast tumor cell lines but not in normal breast tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ALT-PTK6; Breast tumor kinase; deltam5; FLJ42088; protein tyrosine kinase 6; Protein-tyrosine kinase 6; protein-tyrosine kinase BRK; PTK6 protein tyrosine kinase 6; SRC-related intestinal kinase; tyrosine kinase identified from skin; Tyrosine-protein kinase BRK
Gene Aliases: BRK; PTK6; Sik; tks; Tksk
UniProt ID: (Human) Q13882, (Mouse) Q64434
Entrez Gene ID: (Human) 5753, (Mouse) 20459, (Rat) 366275
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of neuron projection development
phosphorylation
cell migration
actin cytoskeleton organization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
innate immune response
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid
negative regulation of signal transduction
ERBB2 signaling pathway
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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