Proteintech

BRN2 Polyclonal Antibody

BRN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BRN2 Antibody (14596-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 14596-1-AP (BRN2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

BRN2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

14596-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BRN2 Fusion Protein Ag6131 (180-443 aa encoded by BC051699)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SMGASNGGL LYSQPSFTVN GMLGAGGQSA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ PPPPPPPQGP PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGGT LPGAEDVYGG SRDTPPHHGV QTPVQ (180-443 aa encoded by BC051699)

Target Information

This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells.

FEBS letters

Liu Q,Tian R,Yu P,Shu M

Mon Nov 01 00:00:00 UTC 2021

Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.

Human molecular genetics

Liu X,Blazejewski SM,Bennison SA,Toyo-Oka K

Thu Mar 25 00:00:00 UTC 2021

HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.

Neuron

Tang T,Zhang Y,Wang Y,Cai Z,Lu Z,Li L,Huang R,Hagelkruys A,Matthias P,Zhang H,Seiser C,Xie Y

Wed Mar 20 00:00:00 UTC 2019

Overexpression of the 14-3-3gamma protein in embryonic mice results in neuronal migration delay in the developing cerebral cortex.

Neuroscience letters

Cornell B,Wachi T,Zhukarev V,Toyo-Oka K

Mon Aug 15 00:00:00 UTC 2016

Overexpression of the 14-3-3gamma protein in embryonic mice results in neuronal migration delay in the developing cerebral cortex.

Neuroscience letters

Cornell B,Wachi T,Zhukarev V,Toyo-Oka K

Mon Aug 15 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 7-Oct; Brain-2; brain-2 class III POU-domain protein; Brain-specific homeobox/POU domain protein 2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Oct-7; Octamer-binding protein 7; Octamer-binding transcription factor 7; OTF-7; POU domain, class 3, transcription factor 2; protein Brn-2

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Gene Aliases: 9430075J19Rik; A230098E07Rik; Brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7; OTF7; POU3F2; POUF3

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UniProt ID: (Human) P20265, (Mouse) P31360

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Entrez Gene ID: (Human) 5454, (Mouse) 18992, (Rat) 29588

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity transcription factor activity, sequence-specific DNA binding protein binding identical protein binding DNA binding sequence-specific DNA binding HMG box domain binding

Process(es)

transcription from RNA polymerase II promoter positive regulation of cell proliferation epidermis development negative regulation of gene expression astrocyte development cerebral cortex radially oriented cell migration forebrain ventricular zone progenitor cell division hypothalamus cell differentiation neurohypophysis development myelination in peripheral nervous system neuron differentiation positive regulation of multicellular organism growth positive regulation of transcription from RNA polymerase II promoter regulation of axonogenesis cellular response to organic substance transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Schwann cell development regulation of cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BRN2 Polyclonal Antibody

BRN2 Antibody (14596-1-AP) in IHC (P)

Product Details

14596-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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