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Invitrogen
BRUCE Polyclonal Antibody
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BRUCE Antibody (PA5-114907) in IHC (P)
Immunohistochemistry analysis of BRUCE in human colorectal cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114907) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-114907
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BIRC6(Accession Q9NR09), corresponding to amino acid residues L4692-E4742.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899543
Product Specific Information
Antibody detects endogenous levels of total BIRC6.
Target Information
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APOLLON; baculoviral IAP repeat-containing 6; Baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6; BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
Gene Aliases: A430032G04Rik; A430040A19Rik; AA501170; APOLLON; BIRC6; BRUCE; D630005A10Rik; KIAA1289; mKIAA1289
UniProt ID: (Human) Q9NR09, (Mouse) O88738
Entrez Gene ID: (Human) 57448, (Mouse) 12211
ubiquitin-protein transferase activity
cysteine-type endopeptidase inhibitor activity
protein binding
ligase activity
ubiquitin conjugating enzyme activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
peptidase inhibitor activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protein phosphorylation
apoptotic process
mitotic nuclear division
positive regulation of cell proliferation
negative regulation of endopeptidase activity
protein ubiquitination
regulation of cytokinesis
regulation of cell proliferation
negative regulation of apoptotic process
cell division
labyrinthine layer development
spongiotrophoblast layer development
negative regulation of extrinsic apoptotic signaling pathway
placenta development
cell cycle
regulation of signal transduction
negative regulation of peptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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