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FIGURE: 1 / 1
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (98%), Rat (99%), Zebrafish (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BTB (POZ) domain containing 7; BTB/POZ domain-containing protein 7
Gene Aliases: BTBD7; FUP1; KIAA1525
UniProt ID: (Human) Q9P203
Entrez Gene ID: (Human) 55727
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