Bioss

BTG1/BTG2 Polyclonal Antibody

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-7526R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human BTG1, amino acids 41-140.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

BTG1 belongs to the BTG family of proteins.FUNCTION: Anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B cell chronic lymphocytic leukemia; translocation t(8;12)(q24;q22) with MYC. BTG2 is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. BTG2 is involved in the regulation of the G1/S transition of the cell cycle. It modulates transcription regulation mediated by ESR1 (referenced from Entrez Gene). BTG2 expression is induced in vivo during neurogenesis, and the gene is transiently expressed in vitro in rat pheochromocytoma PC12 cells after induction of neuronal differentiation by addition of nerve growth factor (NGF); suggesting that BTG2 is functionally significant during the neuronal differentiation process (PMID: 12360398).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Anti-proliferative factor; B-cell translocation gene 1 protein; B-cell translocation gene 1, anti-proliferative; B-cell translocation gene 2; B-cell translocation gene 2, anti-proliferative; BTG; BTG family member 2; BTG family, member 2; BTG1/2; cell surface alloantigen; Early induced gene B-cell translocation gene 2; nerve growth factor-inducible anti-proliferative; NGF-inducible anti-proliferative protein PC3; NGF-inducible anti-proliferative putative secreted protein; NGF-inducible protein TIS21; pheochromacytoma cell-3; Protein BTG1; Protein BTG2

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Gene Aliases: AA959598; Agl; AI426953; An; an-1; APRO1; APRO2; AW546738; BTG1; BTG2; PC3; TIS21

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UniProt ID: (Human) P62324, (Human) P78543, (Rat) Q63073, (Mouse) P62325, (Rat) P27049, (Mouse) Q04211

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Entrez Gene ID: (Human) 694, (Human) 7832, (Rat) 29618, (Mouse) 12226, (Rat) 29619, (Mouse) 12227

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Function(s)
transcription cofactor activity protein binding enzyme binding kinase binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Process(es)
regulation of transcription, DNA-templated negative regulation of cell proliferation cell migration negative regulation of cell growth positive regulation of endothelial cell differentiation positive regulation of myoblast differentiation positive regulation of angiogenesis positive regulation of fibroblast apoptotic process protein methylation response to oxidative stress spermatogenesis spermatid development response to peptide hormone positive regulation of catalytic activity negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated cellular response to DNA damage stimulus associative learning response to mechanical stimulus anterior/posterior pattern specification response to organic substance response to organonitrogen compound response to organic cyclic compound negative regulation of translation dentate gyrus development central nervous system neuron development neuron differentiation neuron projection development skeletal muscle cell differentiation negative regulation of apoptotic process negative regulation of neuron apoptotic process response to electrical stimulus positive regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of neural precursor cell proliferation transcription from RNA polymerase II promoter DNA repair DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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