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Invitrogen
BVES Polyclonal Antibody
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Product Details
PA5-53235
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BVES. Recombinant protein control fragment (Product #RP-91074).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638644
Product Specific Information
Immunogen sequence: LNDPTLNDKK AKKLEHQLSL CTQISMLEMR NSIASSSDSD DGLHQFLRGT SSMSSLHVSS PHQRASAKMK PIEEGAEDDD DVFEPASPNT LKVHQLP
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 25%.
Target Information
Blood vessel epicardial substance (BVES), also designated Popeye protein 1, is a transmembrane protein that plays a role in cell-cell interactions and adhesion, specifically at tight junctions. BVES is composed of an extracellular amino-terminus, three transmembrane domains and a cytoplasmic carboxyl-terminus. It is expressed in the developing coronary vascular system, specifically in the proepicardium, migrating epithelial epicardium, delaminated vasculogenic mesenchyme and vascular smooth muscle cells, where it functions to direct development in heart, epithelial and muscle cells during embryogenesis. BVES accumulates at points of cell-cell contact, such as filopodia and cell borders, and promotes adhesion prior to the arrival of E-cadherin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC42413; POP 1; POPDC 1; Popeye domain-containing protein 1; Popeye protein 1
Gene Aliases: BVES; HBVES; LGMD2X; POP1; POPDC1
UniProt ID: (Human) Q8NE79
Entrez Gene ID: (Human) 11149
positive regulation of receptor recycling
regulation of heart rate
hematopoietic progenitor cell differentiation
response to ischemia
heart development
muscle organ development
skeletal muscle tissue development
regulation of cell shape
vesicle-mediated transport
substrate adhesion-dependent cell spreading
positive regulation of locomotion
regulation of membrane potential
regulation of GTPase activity
vesicle docking
sinoatrial node cell development
cell migration involved in heart development
epithelial cell-cell adhesion
regulation of endocytic recycling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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