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Invitrogen
BZLF1 Polyclonal Antibody
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FIGURE: 1 / 1
BZLF1 Antibody (PA5-144528) in WB
Western blot analysis of BZLF1 in recombinant protein All lanes: BZLF1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1:50,000 dilution Predicted band size: 46 kDa Observed band size: 50 kDa. using a dilution of 1:1,000. Samples were incubated with BZLF1 polyclonal antibody (Product # PA5-144528). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution Predicted band size: 46 kDa Observed band size: 50 kDa. Predicted band size: 46 kDa Observed band size: 50 kDa.
Product Details
PA5-144528
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Epstein-Barr virus BZLF1 protein
Conjugate
Form
Liquid
Concentration
4.9 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3091610
Target Information
Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (PubMed:8404860) (Probable). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome (PubMed:34893887, PubMed:15361873). Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes (PubMed:30926617). Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (PubMed:34893887, PubMed:22022468) (Probable). Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells (PubMed:19325883, PubMed:15361873). BZLF1 and BRLF1 act together to trigger lytic replication (PubMed:10856251, PubMed:15361873). Also binds the lytic origin of replication, oriLyt (PubMed:20808903). Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA (PubMed:15078966). This function is important because the lytic cycle preferentially takes place in host cells arrested in G1 (PubMed:15078966).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Trans-activator protein BZLF1
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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