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Invitrogen
Bedinvetmab Recombinant Canine Monoclonal Antibody
FIGURE: 1 / 1
Bedinvetmab Antibody (MA5-42252) in SDS-PAGE
SDS-PAGE analysis of the recombinant Canine (Canis lupus familiaris) NGF/NGFB protein expressed in CHO cells using a Bedinvetmab biosimilar monoclonal antibody (Product # MA5-42252). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
Product Details
MA5-42252
Product Specifications
Species Reactivity
Dog
Host/Isotype
Dog
/ IgG2, lambda
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Canine (Canis lupus familiaris) NGF/NGFB
Conjugate
Form
Liquid
Concentration
2.9 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.5
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911395
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Target Information
Bedinvetmab is a biosimilar that targets NGF. Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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