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Proteintech
Beta adducin Polyclonal Antibody
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Product Details
14640-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Beta adducin Fusion Protein Ag6223 (1-331 aa encoded by BC065525)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSEETVPEA ASPPPPQGQP YFDRFSEDDP EYMRLRNRAA DLRQDFNLME QKKRVTMILQ SPSFREELEG LIQEQMKKGN NSSNIWALRQ IADFMASTSH AVFPTSSMNV SMMTPINDLH TADSLNLAKG ERLMRCKISS VYRLLDLYGW AQLSDTYVTL RVSKEQDHFL ISPKGVSCSE VTASSLIKVN ILGEVVEKGS SCFPVDTTGF CLHSAIYAAR PDVRCIIHLH TPATAAVSAM KWGLLPVSHN ALLVGDMAYY DFNGEMEQEA DRINLQKCLG PTCKILVLRN HGVVALGDTV EEAFYKIFHL QAACEIQVSA LSSAGGVENL IL (1-331 aa encoded by BC065525)
Target Information
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Add97; adducin 2 (beta); adducin beta; Adducin-63; Beta-adducin; Erythrocyte adducin subunit beta; snoRNA MBII-396
Gene Aliases: 2900072M03Rik; ADD2; add97; ADDB; beta-ADD
UniProt ID: (Human) P35612, (Mouse) Q9QYB8, (Rat) Q05764
Entrez Gene ID: (Human) 119, (Mouse) 11519, (Rat) 24171
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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