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Invitrogen
Bi-1 Monoclonal Antibody (20F565)
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Bi-1 Antibody (MA5-16225) in IHC (P)
Immunohistochemical analysis of Bi-1 in human and mouse TMA, human archicortex, neurons of human dorsal root ganglion. Samples were incubated with Bi-1 monoclonal antibody (Product # MA5-16225) using a dilution of 5 µg/mL. A) overview of stained human and mouse TMA, B-C) immunoreactivity in human archicortex (positive neurons of hippocampal gyrus) at 200X and 400X, D-E) strong immunoreactivity in neurons of... View More
Product Details
MA5-16225
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
20F565
Immunogen
A synthetic peptide made to the N-terminal portion of the human Bax inhibitor 1 protein (between amino acids 1-40) UniProt P55061.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2537743
Target Information
BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bax inhibitor 1; Bax inhibitor-1; BI-1; testis enhanced gene transcript; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
Gene Aliases: 5031406P05Rik; Ab1-011; Ac1-149; BAXI1; BI-1; BI1; Cc1-27; TEGT; TMBIM6
UniProt ID: (Human) P55061, (Rat) P55062, (Mouse) Q9D2C7
Entrez Gene ID: (Human) 7009, (Rat) 24822, (Mouse) 110213
apoptotic process
response to unfolded protein
spermatogenesis
lung development
negative regulation of mRNA cleavage
negative regulation of protein binding
endoplasmic reticulum calcium ion homeostasis
negative regulation of apoptotic process
negative regulation of endoribonuclease activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of endoplasmic reticulum unfolded protein response
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
autophagy
negative regulation of immunoglobulin secretion
response to L-glutamate
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of apoptotic signaling pathway
response to endoplasmic reticulum stress
negative regulation of IRE1-mediated unfolded protein response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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