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Bioss
Biglycan Polyclonal Antibody
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FIGURE: 1 / 4
Biglycan Antibody (BS-7552R) in ICC/IF
Paraformaldehyde-fixed (4%) Human Endothelial Cells were blocked with normal goat serum for 20 mins at 37°C. The cells were then labeled with Biglycan Polyclonal Antibody, Unconjugated (bs-7552R) at 1:50, Overnight at 4°C. Secondary antibody incubation was performed with Goat Anti-Rabbit IgG, Rhodamine B conjugated antibody (bs-0295G-RBITC) at a 1:200 dilution for 40 minutes at 37°C. DAPI (5 µg/mL; blue) was used to stain the cell nuclei.
Product Details
BS-7552R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Biglycan, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transferring growth factor-beta. It may promote neuronal survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Biglycan; bone/cartilage proteclycan 1; Bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; PG S1; PG-S1; small leucine-rich protein 1A; Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)
Gene Aliases: BG; BGN; BSPG1; DSPG1; PG-S1; PGI; SLRR1A
UniProt ID: (Human) P21810, (Mouse) P28653, (Rat) P47853
Entrez Gene ID: (Rabbit) 100008663, (Human) 633, (Mouse) 12111, (Rat) 25181
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
blood vessel remodeling
negative regulation of protein kinase activity
biological_process
cytokine-mediated signaling pathway
extracellular matrix organization
glycosaminoglycan metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
dermatan sulfate biosynthetic process
negative regulation of JAK-STAT cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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