Invitrogen

Bim Recombinant Rabbit Monoclonal Antibody (8H1L4)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

701853

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

8H1L4

Immunogen

Recombinant protein corresponding to Human BIM (aa 1-120)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2610263

Product Specific Information

This antibody is predicted to react with Monkey, Rabbit and Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl-2 like 11; Bcl-2-like protein 11; bcl-2-related ovarian death agonist; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; OTTHUMP00000197013; OTTHUMP00000204247

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Gene Aliases: BAM; BCL2L11; BIM; BOD

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UniProt ID: (Human) O43521

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Entrez Gene ID: (Human) 10018

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Function(s)
protein binding microtubule binding dynein binding
Process(es)
in utero embryonic development B cell homeostasis B cell apoptotic process kidney development protein insertion into mitochondrial membrane involved in apoptotic signaling pathway myeloid cell homeostasis apoptotic process meiosis I cell-matrix adhesion spermatogenesis brain development male gonad development intrinsic apoptotic signaling pathway in response to DNA damage mammary gland development positive regulation of protein homooligomerization response to endoplasmic reticulum stress tube formation odontogenesis of dentin-containing tooth T cell homeostasis positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process ear development positive regulation of cell cycle regulation of organ growth developmental pigmentation regulation of developmental pigmentation spleen development thymus development post-embryonic organ morphogenesis positive regulation of apoptotic process by virus cellular process regulating host cell cycle in response to virus thymocyte apoptotic process positive regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway apoptotic process involved in embryonic digit morphogenesis positive regulation of IRE1-mediated unfolded protein response positive regulation of fibroblast apoptotic process positive regulation of intrinsic apoptotic signaling pathway
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