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Invitrogen
Blimp-1 Monoclonal Antibody (E.995.1)
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FIGURE: 1 / 4
Blimp-1 Antibody (MA5-14879) in WB
Western Blot was performed using Anti-Blimp-1 Monoclonal Antibody (E.995.1) (Product # MA5-14879) and a 92 kDa band corresponding to PR domain zinc finger protein 1 was observed across cell lines and tissue tested; was downregulated in Daudi upon MG132 treatment and upregulated in MDA-MB-231 upon TGF beta1 treatment. Whole cell extracts (30 µg lysate) of Raji (Lane 1), A549 (Lane 2), Daudi (Lane 3), Daudi treated with MG132 (1 µMpl/L for 24 hrs) (Lane 4), Ramos (Lane 5), MDA-MB-231 (Lane 6), MDA-MB-231 treated with TGF beta1 (5 ng/mL for 2... View More
Product Details
MA5-14879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
E.995.1
Immunogen
Synthetic peptide corresponding to residues surrounding Val90 of human PRDI-BF1
Conjugate
Form
Liquid
Concentration
10 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11004709
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B lymphocyte-induced maturation protein 1; B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; BLIMP-1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; RP1-134E15.1
Gene Aliases: b2b1765Clo; Blimp-1; BLIMP1; PRDI-BF1; PRDM1; ZNFPR1A1
UniProt ID: (Human) O75626, (Mouse) Q60636
Entrez Gene ID: (Human) 639, (Mouse) 12142
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
methyltransferase activity
histone deacetylase binding
metal ion binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
morphogenesis of a branching structure
maternal placenta development
heart valve development
ventricular septum development
transcription, DNA-templated
germ cell development
post-embryonic development
positive regulation of gene expression
negative regulation of B cell proliferation
negative regulation of lipopolysaccharide-mediated signaling pathway
methylation
regulation of natural killer cell differentiation
regulation of extrathymic T cell differentiation
aorta development
eye photoreceptor cell development
cell fate commitment
positive regulation of B cell differentiation
artery morphogenesis
regulation of NK T cell differentiation
intestinal epithelial cell development
trophoblast giant cell differentiation
coronary vasculature development
sebum secreting cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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