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NeoBiotechnologies
Blood Group Antigen H Type 2 (CD173) Monoclonal Antibody (A46-B/B10)
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Product Details
28-MSM2-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
A46-B/B10
Immunogen
Human breast cancer MCF-7 cells
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The H antigen is a precursor to the ABO blood groupantigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs bycomplement-mediated lysis. Therefore, people with Bombay phenotype can receive blood only from otherhhdonors, although they can donate as though they were type O. Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains threeexonsthat span more than 5kbof genomic DNA, and encodes thefucosyltransferasethat produces the H antigen on RBCs. The H antigen is a carbohydrate sequence withcarbohydrateslinked mainly to protein (with a minor fraction attached toceramidemoiety).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A transferase; A1-specific alpha 1-3-N-acetylgalactosaminyltransferase; ABH; ABO A3 transferase; ABO glycosyltransferase; ABO weak transfer; B transferase; B(A) alpha-1,3-galactosyltransferase; BG-H; BG-H1; fucosylglycoprotein; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycosyltransferase A; glycosyltransferase B; Histo-blood group A transferase; histo-blood group A2 transferase; Histo-blood group ABO system transferase; Histo-blood group B transferase; NAGAT; Transferase; transferase A
Gene Aliases: A3GALNT; A3GALT1; ABO; GTB; NAGAT
UniProt ID: (Human) P16442
Entrez Gene ID: (Human) 28
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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