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Mouse anti Bordetella Pertussis Toxin antibody, clone 1280/204 is reactive with Bordetella pertussis toxin in a simple ELISA. Reactivities with other organisms have not yet been determined.
B. pertussis has the ability to inhibit the function of the host's immune system. The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is phagocytes convert too much ATP to cyclic AMP, which can cause disturbances in cellular signaling mechanisms, and prevent phagocytes from correctly responding to an infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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