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Immunogen sequence: SHGTYYECEP RGGQQPLEFS GGRAGPGELG DMCEHEASID LSAYIESGEE QLLSDLFAVK PAPEARGLKG PGTPAFPHYL PPDPRPFAYP PHTFGPDRKA LGPGIYSSPG SYDPRAVAVK EEPR
C/EBP alpha regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP alpha uses a bipartite structural motif to bind DNA. Two protein chains dimerize through a set of amphipathic alpha helices termed the leucine zipper. Highly basic polypeptide regions emerge from the zipper to form a linked set of DNA contact surfaces. C/EBP alpha appears to function exclusively in terminally-differentiated, growth-arrested cells. Additional family members include C/EBP beta, C/EBP gamma, C/EBP delta and C/EBP epsilon, all of which exhibit similar DNA-binding specificities and affinities to C/EBP alpha. Furthermore, C/EBP beta and C/EBP delta readily form heterodimers both with each other as well as with C/EBP alpha.
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Protein Aliases: C EBP; C/EBP epsilon; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer-binding protein epsilon
Gene Aliases: C/EBP-epsilon; CEBPE; CRP1
UniProt ID: (Human) Q15744
Entrez Gene ID: (Human) 1053
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