Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
C11orf54 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
23251-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C11orf54 Fusion Protein Ag19731 (1-310 aa encoded by BC007110)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RSGLWVFCY RDRLVMQKGL KDNFADVQVS VVDCPDLTKE PFTFPVKGIC GKTRIAEVGG VPYLLPLVNQ KKVYDLNKIA KEIKLPGAFI LGAGAGPFQT LGFNSEFMPV IQTESEHKPP VNGSYFAHVN PADGGCLLEK YSEKCHDFQC ALLANLFASE GQPGKVIEVK AKRRTGPLNF VTCMRETLEK HYGNKPIGMG GTFIIQKGKV KSHIMPAEFS SCPLNSDEEV NKWLHFYEMK APLVCLPVFV SRDPGFDLRL EHTHFFSRHG EGGHYHYDTT PDIVEYLGYF LPAEFLYRID QPKETHSIGR D (1-310 aa encoded by BC007110)
Target Information
C11orf54, also known as Chromosome 11 Open Reading Frame 54, is an ester hydrolase highly conserved across various species. Located on chromosome 11, the gene is identified as a biomarker associated with renal cancers, although its precise biological function is not fully elucidated. Research has shown that C11orf54 plays a role in DNA repair mechanisms, particularly by blocking chaperone-mediated autophagy (CMA). Silencing this gene reduces cellular proliferation and heightens DNA damage and apoptosis when cells are treated with cisplatin, a common chemotherapeutic agent. This suggests C11orf54's involvement in cancer pathology, particularly its potential impact on DNA repair pathways, thereby supporting cell survival post DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ester hydrolase C11orf54; Ester hydrolase C11orf54 homolog
Gene Aliases: C11orf54; LP4947; PTD012; PTOD012
UniProt ID: (Human) Q9H0W9, (Rat) Q5U2Q3
Entrez Gene ID: (Human) 28970, (Rat) 363016
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support