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Product Details
PA5-58416
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human C12orf41. Recombinant protein control fragment (Product #RP-97768).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638727
Product Specific Information
Immunogen sequence: FSDDLDVVGD GMQCPPSPLL FDPSLTLEDH LVKEIAEDPV DILGQMQMAG DGCRSQGSRN SEKASAPLSQ SGLATANGKP EP
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 76%.
Target Information
The C12orf41 gene, also known as CFAP70 (Cilia and Flagella Associated Protein 70), is located on chromosome 12 and encodes a protein that is essential for the proper function of cilia and flagella. The CFAP70 protein plays a critical role in the assembly and maintenance of axonemal structures, which are core components of cilia and flagella. Cilia and flagella are vital for various cellular processes, including motility, fluid movement across cell surfaces, and signal transduction. Mutations in CFAP70 have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory tract infections, abnormal situs (organ positioning), and infertility due to defective motility of cilia and flagella. CFAP70 is also involved in the regulation of dynein arms and radial spokes, which are necessary for the effective beating of cilia and flagella. Research into CFAP70 continues to uncover its multifaceted roles in cellular function and its potential implications in ciliopathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KAT8 regulatory NSL complex subunit 2; Non-specific lethal 2 homolog; NSL complex protein NSL2
Gene Aliases: C12orf41; KANSL2; NSL2
UniProt ID: (Human) Q9H9L4
Entrez Gene ID: (Human) 54934
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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