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Invitrogen
C12orf66 Polyclonal Antibody
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Product Details
PA5-65744
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human C12orf66. Recombinant protein control fragment (Product #RP-106420).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2664442
Product Specific Information
Immunogen sequence: EKVYHSLTYL GQKLGGQSFF SRKDSIRTIY TSLHNELKKV VTGRGALGGT APHVEELLSH LSEQLCFFVQ ARMEMADFYE KMYTLSTQKF INA
Target Information
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KICSTOR complex protein C12orf66; KICSTOR subunit 2; UPF0536 protein
Gene Aliases: C12orf66; KICS2
UniProt ID: (Human) Q96MD2
Entrez Gene ID: (Human) 144577
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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