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Immunogen sequence: AVQVSRRTIS SNSFSPEVFV LPVDVEKENA HFYVADMIIS AMEKMKCNIL SQQQTESWSK EVSGLLGSDQ PDSEMTFDTN IKQESGSSTS SYSGYEGCAV LQVSPVTETR TYHDVKEICK CDVDEFVILE LGDF
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 49%.
This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KIAA0226-like; Pacer; Protein associated with UVRAG as autophagy enhancer; Protein Rubicon-like
Gene Aliases: C13orf18; KIAA0226L; RUBCNL
UniProt ID: (Human) Q9H714
Entrez Gene ID: (Human) 80183
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